Association Between Serum N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) Levels and Frailty in Community-Dwelling Old-Old Older Adults ― SONIC Study ―
Elevated serum NT-proBNP levels are independently associated with frailty onset in community-dwelling old-old older adults, driven by the interaction between potential cardiac overload or asymptomatic HF and frailty. Serum NT-proBNP may be a useful tool for identifying frailty associated with cardiac overload.
Authors
- Yuya Akagi (ORCID: https://orcid.org/0000-0001-7974-9580)
- Marlon Maus
- Yukie Masui (ORCID: https://orcid.org/0000-0001-6197-6697)
- Hiroshi Akasaka (ORCID: https://orcid.org/0000-0003-0238-8320)
- Kazunori Ikebe (ORCID: https://orcid.org/0000-0001-5696-6785)
- Michiko Kido
- Yoichi Takami (ORCID: https://orcid.org/0000-0001-9018-6707)
- Yasuyuki Gondo (ORCID: https://orcid.org/0000-0002-9805-2807)
- Kayo Godai (ORCID: https://orcid.org/0000-0003-2875-0869)
- Yasumichi Arai (ORCID: https://orcid.org/0000-0003-1746-965X)
- Takeshi Nakagawa (ORCID: https://orcid.org/0000-0001-5533-3169)
- Kei Kamide
- Kōichi Yamamoto (ORCID: https://orcid.org/0000-0003-0107-9315)
- Mai Kabayama (ORCID: https://orcid.org/0000-0003-1394-1152)
- Saori Yasumoto
- Saya Terada (ORCID: https://orcid.org/0000-0001-9437-967X)
- Takumi Hirata
Institutions
- Keio University (JP)
- Osaka University of Human Sciences (JP)
- Metropolitan University (RS)
- Osaka Health Science University (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Berkeley Public Health Division (US)
- Osaka International University (JP)
- University of California, Berkeley (US)
- The University of Osaka (JP)
Publication Details
- Journal
- Circulation Reports
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1253/circrep.cr-25-0110
- Citations
- 1
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science