Low Glucose Boosts Exosomal TRAIL and Shapes the Immune Niche of the Lung

Major Finding: Low glucose or impaired metabolism promotes lung metastasis by altering immune cell function.Concept: ER stress driven by low glucose induces exosomal TRAIL, activating macrophages and NK cell exhaustion.Impact: Exosomal TRAIL levels may have utility as an early marker of metastasis and recurrence.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-073
Primary Topic
Viral Infections and Immunology Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Low Glucose Boosts Exosomal TRAIL and Shapes the Immune Niche of the Lung

Cancer Discovery
Viral Infections and Immunology Research
article

Low Glucose Boosts Exosomal TRAIL and Shapes the Immune Niche of the Lung

article en

Abstract

Major Finding: Low glucose or impaired metabolism promotes lung metastasis by altering immune cell function.Concept: ER stress driven by low glucose induces exosomal TRAIL, activating macrophages and NK cell exhaustion.Impact: Exosomal TRAIL levels may have utility as an early marker of metastasis and recurrence.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 67%
Viral Infections and Immunology Research
DOISourceOpenAlex
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Low Glucose Boosts Exosomal TRAIL and Shapes the Immune Niche of the Lung · Cancer Discovery (2025) | TGRS Research Map | TGRS