Graph Theoretical Analysis of SARS-COV-2 Spike Protein

The spike protein of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the main surface antigen of the coronavirus. The global pandemic that affected most countries and territories in 2019 was caused by the emergence of the SARS-CoV-2 spike protein. Graph theoretical analysis plays an important role in biological networks. First, we construct the Pt-graph of SARS-CoV-2 based on the physicochemical properties and adjacency of amino acids in the corresponding peptide/protein in SARS-CoV-2. By analyzing the of Pt-graph, we receive some observations about the relations among the amino acids, physiochemical properties of amino acids and peptide/protein, and it will help in the development of and drug design. In this study, we analyze the Pt-graph of the SARS-CoV-2 spike protein to examine its structural properties.