High peak viraemia followed by spontaneous HIV‐1 control in women living with HIV‐1 subtype A1 in East Africa
Our findings confirm the role of HIV-1 subtype A1 in mediating viral control. The fact that controllers showed high viral loads in acute infection indicates that these viruses were not intrinsically impaired for replication, underlining the intersection between host immunity and favourable genotypes in the subsequent control of HIV-1. These data suggest that conducting HIV-1 remission studies in East Africa could provide favourable conditions to achieve durable post-treatment control of viraemia.
Authors
- Sodsai Tovanabutra (ORCID: https://orcid.org/0000-0002-5946-4227)
- Lucas Maganga (ORCID: https://orcid.org/0000-0001-7519-0628)
- Phuc Pham (ORCID: https://orcid.org/0000-0003-2354-7546)
- Bethany L. Dearlove (ORCID: https://orcid.org/0000-0003-3653-4592)
- Eric Sanders‐Buell (ORCID: https://orcid.org/0000-0002-1694-0529)
- Shida Shangguan (ORCID: https://orcid.org/0000-0003-4471-5318)
- Sandhya Vasan (ORCID: https://orcid.org/0000-0002-6378-6288)
- Leigh Anne Eller (ORCID: https://orcid.org/0000-0003-2043-1513)
- Julie A. Ake (ORCID: https://orcid.org/0000-0003-3831-5828)
- Éric Lewitus (ORCID: https://orcid.org/0000-0001-6459-2437)
- Philip K. Ehrenberg (ORCID: https://orcid.org/0000-0002-8695-4301)
- Meera Bose (ORCID: https://orcid.org/0000-0003-4151-0958)
- Morgane Rolland (ORCID: https://orcid.org/0000-0003-3650-8490)
- Hannah Kibuuka (ORCID: https://orcid.org/0000-0002-2293-1944)
- Sorachai Nitayaphan (ORCID: https://orcid.org/0000-0001-6935-1405)
- Merlin L. Robb (ORCID: https://orcid.org/0000-0003-3949-9649)
- Fredrick Sawe
- Hongjun Bai (ORCID: https://orcid.org/0000-0002-3501-3974)
- Yifan Li (ORCID: https://orcid.org/0000-0001-7038-2671)
- Shana Miller
- Rasmi Thomas
- Yvonne V Rosario
Institutions
- Henry M. Jackson Foundation (US)
- Makerere University Walter Reed Project (UG)
- United States Army Medical Research Directorate - Africa (KE)
- Mbeya University of Science and Technology (TZ)
- Armed Forces Research Institute of Medical Science (TH)
- National Institute for Medical Research (TZ)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Journal of the International AIDS Society
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/jia2.70016
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- U.S. Department of Defense
- Henry M. Jackson Foundation