Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation
Sex differences in repolarisation reserve, calcium handling, and anatomy are key factors underpinning ECG and LVEF responses to drugs. Specifically, under calcium block, females showed more preserved LVEF, while under hERG block, females showed more QTc prolongation.
Authors
- Jakub Tomek (ORCID: https://orcid.org/0000-0002-0157-4386)
- Hector Martinez‐Navarro (ORCID: https://orcid.org/0000-0003-0234-2605)
- Zhinuo Jenny Wang (ORCID: https://orcid.org/0000-0001-5325-909X)
- Blanca Rodríguez (ORCID: https://orcid.org/0000-0001-6361-3339)
- Julià Camps (ORCID: https://orcid.org/0000-0002-6491-2565)
- Rubén Doste (ORCID: https://orcid.org/0000-0003-4187-4970)
- Maxx Holmes (ORCID: https://orcid.org/0000-0002-2299-9455)
- Hannah Smith (ORCID: https://orcid.org/0000-0003-1271-162X)
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100479
- Citations
- 3
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 4.16