Annonacin induces apoptosis and modulates programmed death-ligand 1 and interferon-gamma expression in triple-negative breast cancer: Integrated in silico and in vitro analysis
Annonacin modulates immune checkpoint (PD-L1) and cytokine (IFN-γ) expression while promoting apoptosis in TNBC cells. These results highlight its potential as a dual-function anticancer agent, warranting further preclinical evaluation for use as a monotherapy or in combination with immunotherapies.
Authors
- Mustofa Helmi Effendi (ORCID: https://orcid.org/0000-0001-9727-411X)
- Rochmah Kurnijasanti (ORCID: https://orcid.org/0000-0002-7069-6205)
- Retina Yunani (ORCID: https://orcid.org/0009-0003-6125-5496)
- Sri Agus Sudjarwo (ORCID: https://orcid.org/0000-0002-7998-7500)
- Nurul Hidayah (ORCID: https://orcid.org/0000-0002-1338-3667)
Institutions
- Universitas Airlangga (ID)
- Universitas Wijaya Kusuma Surabaya (ID)
Publication Details
- Journal
- Veterinary World
- Published
- 2025-08-01
- DOI
- https://doi.org/10.14202/vetworld.2025.2241-2251
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Gadjah Mada