Comparative protective effects of rosuvastatin and ramipril against doxorubicin-induced testicular toxicity in rats: A multimodal evaluation of oxidative stress and reproductive parameters
Ramipril and rosuvastatin mitigate doxorubicin-induced testicular toxicity through antioxidant mechanisms. Ramipril demonstrated superior efficacy in preserving reproductive hormone levels and sperm function. These findings highlight its potential as a fertility-protective agent during chemotherapy. Further long-term and mechanistic studies are warranted.
Authors
- Guruprasad Kalthur (ORCID: https://orcid.org/0000-0002-4554-2917)
- Shreya Hegde (ORCID: https://orcid.org/0000-0002-9913-1427)
- G Shivaprakash
- Bharti Chogtu Magazine (ORCID: https://orcid.org/0000-0003-2615-9928)
- B. Anisha
Institutions
- Manipal Academy of Higher Education (IN)
- Kasturba Medical College, Manipal (IN)
Publication Details
- Journal
- Veterinary World
- Published
- 2025-08-01
- DOI
- https://doi.org/10.14202/vetworld.2025.2264-2272
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kasturba Medical College, Manipal