Pregnancy exacerbates neutrophil responses in murine lungs and alters gut microbiota composition after cigarette smoke exposure
In conclusion, pregnancy as well as CS exposure induce differences in lung transcriptomic responses which might drive exacerbated lung inflammatory responses measured as neutrophil influx and activity. Microbiota functional and compositional states are also affected by both pregnancy and CS exposure, possibly indicating a gut-lung bidirectional effect.
Authors
- Johan Garssen (ORCID: https://orcid.org/0000-0002-8678-9182)
- Ali Dehghani (ORCID: https://orcid.org/0000-0003-1815-9434)
- Jeroen van Bergenhenegouwen (ORCID: https://orcid.org/0000-0001-8517-4904)
- Gert Folkerts (ORCID: https://orcid.org/0000-0003-0630-2192)
- Saskia Braber (ORCID: https://orcid.org/0000-0002-6835-9787)
- Thea Leusink-Muis (ORCID: https://orcid.org/0000-0003-4986-5497)
- Lei Wang (ORCID: https://orcid.org/0000-0003-0855-3526)
- Ingrid van Ark
- Eirini Styla
Institutions
- University Medical Center Groningen (NL)
- Utrecht University (NL)
- Danone (Netherlands) (NL)
- Pharmo Institute (NL)
- Public Health Service of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1590290
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Danone