Immunological profiling in type 2 diabetes mellitus and type 2 diabetic kidney disease: insights from single-cell LacNAc sequencing
This study identifies immunological alterations in T2DM and T2DKD, implicating neutrophil-mediated inflammation and NET formation in T2DKD progression. Correlative data suggest that targeting ROS and the CXCL8/CXCR2 pathway may represent potential therapeutic directions, though preclinical validation is warranted.
Authors
- Mengyun Xiao (ORCID: https://orcid.org/0000-0001-5866-3569)
- Xiaoyan Pu
- Xiaohui Zhu (ORCID: https://orcid.org/0000-0001-9146-8909)
- Xiang Gao (ORCID: https://orcid.org/0000-0001-6397-5639)
- Ru Wang (ORCID: https://orcid.org/0000-0003-2106-9800)
- Jing Chen (ORCID: https://orcid.org/0000-0002-6227-7393)
- Zigan Xu
- Shaodong Luan
- Yaxuan Wang
Institutions
- Qinghai University (CN)
- Longgang Central Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fendo.2025.1550925
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00