Risk factors for renal impairment in primary aldosteronism: a retrospective study
This study demonstrates that renal impairment is more pronounced in PA patients than in those with EH. Notably, the classic APA subtype exhibits particularly severe damage, specifically manifested by elevated urinary microalbumin excretion. Furthermore, concomitant hypokalemia in PA patients is associated with more severe renal impairment. Hypokalemia and increased 24-hour urinary potassium excretion emerge as key risk factors for renal damage within this patient population.
Authors
- Siying Wu (ORCID: https://orcid.org/0000-0003-0576-386X)
- Chaoping Wei (ORCID: https://orcid.org/0009-0003-1520-7768)
- Huang Jing (ORCID: https://orcid.org/0000-0002-9741-8264)
- Shanshan Chen (ORCID: https://orcid.org/0000-0001-9723-2403)
- Sen Li (ORCID: https://orcid.org/0000-0003-4496-5050)
- Jianling Li (ORCID: https://orcid.org/0000-0002-9721-8086)
- Jie Yu
- Lixia Wei (ORCID: https://orcid.org/0000-0003-2116-2394)
- Mei-Lan Chen (ORCID: https://orcid.org/0000-0002-0461-1066)
- Shuitao Qin
- Shuangbei Zhu
Institutions
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fendo.2025.1606182
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- National Natural Science Foundation of China
- Guangxi Key Research and Development Program