Evaluation of cell-free DNA from papanicolaou smears and peripheral blood to detect endometrial cancer
Multi-gene panels can detect tumor-derived DNA in cfDNA from both blood and Pap smears of patients with EC, with Pap smear cfDNA potentially offering higher efficacy for liquid biopsies in EC. This approach could complement tissue biopsies for early diagnosis and risk stratification, warranting further investigation into the clinical utility of liquid biopsies for EC management.
Authors
- Jiaxin Yang (ORCID: https://orcid.org/0000-0002-1276-1136)
- Yao Wang (ORCID: https://orcid.org/0000-0003-4174-755X)
- Mei Yu (ORCID: https://orcid.org/0000-0002-6070-2456)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fonc.2025.1570938
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Peking Union Medical College Hospital
- Peking Union Medical College
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine