TCR and BCR repertoire analysis reveals distinct signatures between benign and malignant ovarian tumors
Our study highlights the critical role of the adaptive immune repertoire in distinguishing between benign and malignant ovarian tumors. TCR demonstrated more distinct spatial distribution patterns between benign and malignant states, suggesting its potential as a more sensitive biomarker for ovarian tumor detection. These findings provide new insights into the immunological landscape of ovarian tumors and offer a promising avenue for early diagnosis and prognosis assessment.
Authors
- Dongli Zhao (ORCID: https://orcid.org/0009-0000-8372-8811)
- Enhui Jin (ORCID: https://orcid.org/0009-0000-9916-9508)
- Zhonghuang Wang (ORCID: https://orcid.org/0000-0002-1268-883X)
- Yuanguang Meng (ORCID: https://orcid.org/0000-0002-4957-3999)
- Bixia Tang
- Zhenglin Du (ORCID: https://orcid.org/0000-0003-2147-3475)
- Zhe Zhang (ORCID: https://orcid.org/0000-0003-2365-2362)
- Hailong Kang (ORCID: https://orcid.org/0000-0002-9969-2486)
- Wenming Zhao
Institutions
- Beijing Institute of Genomics (CN)
- Chinese PLA General Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fonc.2025.1630707
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80