Effect of high intakes of protein-only and carbohydrate-only on plasma metabolites and hormones, in addition to nitrogen excretion
CHO increased plasma insulin more than PRO. The PRO induced insulin response was independent of glucose and mediated by the increase in plasma amino acids and GLP-1. Interestingly, the GLP-1 response was larger following PRO and remained elevated after 240 minutes, whereas the GIP response was larger following CHO. Additionally, protein-only ingestion increased urinary nitrogen excretion, mainly between 2 to 8 hours after intake, with elevated excretion persisting up to 24 hours.
Authors
- Lotte L. K. Nielsen
- Matthieu Clauss (ORCID: https://orcid.org/0000-0002-7948-9288)
- Bjørn Steen Skålhegg (ORCID: https://orcid.org/0000-0002-3481-8084)
- C. Puissant
- Per Bendix Jeppesen (ORCID: https://orcid.org/0000-0001-8042-7554)
- Nasser E. Bastani (ORCID: https://orcid.org/0000-0001-9404-9662)
- Jørgen Jensen (ORCID: https://orcid.org/0000-0001-5851-220X)
Institutions
- University of Oslo (NO)
- Aarhus University Hospital (DK)
- Nutrition Sciences (Belgium) (BE)
- Norwegian School of Sport Sciences (NO)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fendo.2025.1618142
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Norges Idrettshøgskole