Down syndrome burden in China and globally: a comparative analysis of 1990–2021 trends and future projections based on GBD 2021 database

From 1990 to 2021, the disease burden of DS declined in China and globally. China's decline in ASMR and ASDR outpaced the global level, though ASIR and ASPR remained higher. To further reduce DS burden, future efforts should prioritize early identification, counseling for informed decision-making, and equitable access to quality lifelong multidisciplinary support for affected individuals.

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Publication Details

Journal
Frontiers in Public Health
Published
2025-08-11
DOI
https://doi.org/10.3389/fpubh.2025.1632250
Citations
3
Primary Topic
Chronic Disease Management Strategies
Type
article
Field-Weighted Citation Impact
4.06
Controls
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article

Down syndrome burden in China and globally: a comparative analysis of 1990–2021 trends and future projections based on GBD 2021 database

Xin Tu, Junkun Chen, Ming Tang
3 citations
Frontiers in Public Health
Chronic Disease Management Strategies
4.06
article

Down syndrome burden in China and globally: a comparative analysis of 1990–2021 trends and future projections based on GBD 2021 database

Xin Tu, Junkun Chen, Ming Tang
article en
3 citations

Abstract

From 1990 to 2021, the disease burden of DS declined in China and globally. China's decline in ASMR and ASDR outpaced the global level, though ASIR and ASPR remained higher. To further reduce DS burden, future efforts should prioritize early identification, counseling for informed decision-making, and equitable access to quality lifelong multidisciplinary support for affected individuals.

Frontiers in Public HealthVol. 13
Ganzhou People's Hospital (CN), Gansu Provincial Center for Disease Control and Prevention (CN)
Good health and well-being
Openalex Percentile: Top 6%
Chronic Disease Management Strategies
4.06
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Down syndrome burden in China and globally: a comparative analysis of 1990–2021 trends and future projections based on GBD 2021 database — Xin Tu, Junkun Chen, et al. · Frontiers in Public Health (2025) | TGRS Research Map | TGRS