Comparison of viral phenotype and inflammatory biomarker responses in acute HIV-1 subtype A and C infections
Overall, the data presented here argue against TFV RC as the basis for different pathogenic outcomes in the subtypes A and C. Moreover, levels of inflammatory cytokines that might drive disease progression were similar during acute infection indicating that additional studies are required to understand the mechanism underlying differences in disease progression between the two subtypes. For both subtypes, high levels of ITAC during acute HIV-1 infection are linked to rapid disease progression.
Authors
- Jake W. Rhodes (ORCID: https://orcid.org/0000-0001-9507-4894)
- Rui Xu (ORCID: https://orcid.org/0000-0003-1294-3367)
- Etienne Karita (ORCID: https://orcid.org/0000-0001-9475-5436)
- Martin J. Deymier
- Susan Allen (ORCID: https://orcid.org/0000-0002-9150-3898)
- Elina El-Badry
- Samantha McInally
- William Kilembe (ORCID: https://orcid.org/0000-0002-9012-7325)
- Daniel T. Claiborne (ORCID: https://orcid.org/0000-0002-2091-1456)
- Qianhong Qin
- Jill Gilmour
- Zachary Ende (ORCID: https://orcid.org/0000-0002-0721-6205)
- Eric Hunter
- Ling Yue
Institutions
- Centre for Infectious Disease Research in Zambia (ZM)
- Emory Healthcare (US)
- Emory University (US)
- Imperial College London (GB)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fmicb.2025.1649731
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases