Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis
ZQG ameliorates UC by modulating macrophage plasticity through the PPAR-γ/NF-κB/STAT1 axis, a mechanism validated <i>in vitro</i> as PPAR-γ-dependent. These findings elucidate its clinical efficacy and support its use as a multi-target UC therapy.
Authors
- Zilong Li (ORCID: https://orcid.org/0000-0003-2425-5334)
- Shuqing Xu (ORCID: https://orcid.org/0000-0001-7010-4604)
- Kuo‐Tung Tang (ORCID: https://orcid.org/0000-0002-5468-1329)
- Xiaoli Fang
- Heng Deng (ORCID: https://orcid.org/0000-0002-2199-8960)
- Ming Li (ORCID: https://orcid.org/0000-0001-8270-2070)
- Rui Ding (ORCID: https://orcid.org/0000-0003-0406-5939)
Institutions
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fphar.2025.1646545
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Anhui University
- Anhui University of Chinese Medicine