Conversational AI agent for precision oncology: AI-HOPE-WNT integrates clinical and genomic data to investigate WNT pathway dysregulation in colorectal cancer
AI-HOPE-WNT is the first dedicated AI platform for WNT pathway analysis in CRC. By combining natural language interaction with automated, high-throughput bioinformatics, it democratizes access to pathway-specific precision oncology research. The platform is freely available at: https://github.com/Velazquez-Villarreal-Lab/AI-HOPE-WNT.
Authors
- Enrique Velazquez‐Villarreal (ORCID: https://orcid.org/0000-0002-3603-6414)
- Ei-Wen Yang
- Brigette Waldrup (ORCID: https://orcid.org/0009-0009-5991-9779)
Institutions
- City Of Hope National Medical Center (US)
- City of Hope (US)
Publication Details
- Journal
- Frontiers in Artificial Intelligence
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/frai.2025.1624797
- Citations
- 8
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- Comprehensive Cancer Center, City of Hope
- National Institutes of Health
- National Cancer Institute
- Moonshot Research and Development Program
- Cancer Moonshot