Young-onset biliary tract cancers: Characteristics, treatment patterns, and patient outcomes
The study underscores the scientific justification for investigating age-related differences in biliary tract cancers, revealing that patients with young-onset biliary tract cancer have improved survival outcomes and a higher prevalence of actionable molecular alterations, particularly <i>FGFR2</i> fusions. Physicians can apply these results by incorporating molecular profiling and targeted therapies earlier in the treatment plan for younger patients, potentially improving their prognosis and quality of life. However, it is crucial to consider the study's limitations, such as the retrospective design and potential selection bias, to avoid overgeneralization and ensure appropriate application of the findings in clinical practice and future research.
Authors
- Marc Hilmi (ORCID: https://orcid.org/0000-0003-4762-6740)
- D. López-Valbuena (ORCID: https://orcid.org/0000-0002-8458-516X)
- T. Anthony (ORCID: https://orcid.org/0009-0009-0152-4416)
- Tian V. Tian (ORCID: https://orcid.org/0000-0002-9906-0980)
- Leony Antoun
- T. Pudlarz (ORCID: https://orcid.org/0009-0006-6591-2213)
- Robine Adrien (ORCID: https://orcid.org/0000-0001-8708-1664)
- C. Gloria (ORCID: https://orcid.org/0000-0001-5657-5979)
- Michel Ducreux (ORCID: https://orcid.org/0000-0001-8649-7449)
- Teresa Macarulla (ORCID: https://orcid.org/0000-0002-5856-4082)
- Valérie Boige (ORCID: https://orcid.org/0000-0002-7817-4663)
- A. Tarabay (ORCID: https://orcid.org/0000-0002-3804-3554)
- H. Antoine (ORCID: https://orcid.org/0000-0003-2869-7551)
- David Malka
- S. Cristina
- Shaposhnikova Natalia
- Antoine Italiano
- Castet Florián
- Maximiliano Gelli (ORCID: https://orcid.org/0000-0001-9807-4021)
- Valéry Marine (ORCID: https://orcid.org/0000-0002-7787-6911)
- García-Galea Eduardo (ORCID: https://orcid.org/0000-0003-4699-0786)
- Boilève Alice (ORCID: https://orcid.org/0000-0003-3708-4909)
- Matthieu Delaye (ORCID: https://orcid.org/0000-0002-2435-4757)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Lille (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Lille’s Cardiology Hospital (FR)
- Institute Mutualiste Montsouris (FR)
- Vall d'Hebron Hospital Universitari (ES)
- Institut Bergonié (FR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101550
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00