RAC1 as a novel therapeutic target for acute liver failure
Acute liver failure (ALF) is a life-threatening condition characterized by severe inflammation and oxidative stress for which there are limited treatment options. Our study provides strong scientific justification for targeting the RAC1 protein, demonstrating that its pharmacological inhibition with 1D-142 reduces liver injury, immune cell infiltration, and oxidative damage in murine models of ALF and in human liver explants. These findings identify RAC1 as a novel therapeutic target and provide translational support for its potential clinical application in ALF. RAC1-targeted therapy merits further studies in clinical settings.
Authors
- Ali Canbay (ORCID: https://orcid.org/0000-0001-6069-7899)
- Andrea A. Barquero (ORCID: https://orcid.org/0000-0002-3341-9719)
- Bárbara Bueloni (ORCID: https://orcid.org/0000-0002-6187-0910)
- Julieta Comin
- Esteban Fiore (ORCID: https://orcid.org/0000-0003-1059-1695)
- María José Cantero
- Catalina Atorrasagasti (ORCID: https://orcid.org/0000-0002-4794-3423)
- Martín Fauda (ORCID: https://orcid.org/0000-0003-4335-1874)
- Guillermo Mazzolini (ORCID: https://orcid.org/0000-0002-1450-8441)
- Lucia Gandolfi Donadío (ORCID: https://orcid.org/0009-0009-6126-0520)
- Juan Bayo (ORCID: https://orcid.org/0000-0003-3999-0841)
- Lucia Lameroli
- Francisco Alejandro González Orozco (ORCID: https://orcid.org/0000-0001-8471-0330)
- Matias S Ciarlantini
- Daiana Ganiewich
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Austral University (AR)
- Universidad de Buenos Aires (AR)
- Fundación Instituto Leloir (AR)
- National Institute of Industrial Technology (AR)
- Centro Científico Tecnológico - San Juan (AR)
- Hospital Universitario Austral (AR)
- Spectrum Research (United States) (US)
- Fundación Ciencias Exactas y Naturales (AR)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101547
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00