Identification and validation of expression and functions of ferroptosis-related gene HILPDA in early-onset preeclampsia placentas
Our study establishes HILPDA as a central mechanistic regulator involved in placental immune dysregulation and trophoblast migration in EOPE pathogenesis. The identified biomarkers PART1 and HILPDA-associated pathways may offer novel diagnostic and therapeutic targets for EOPE management, which contribute to reduce maternal morbidity and prevent perinatal mortality in this catastrophic pregnancy syndrome.
Authors
- Yafen Tao
- Chengli Dou
- Huijuan Chen (ORCID: https://orcid.org/0000-0002-5765-4422)
- Jiaojiao Fei
- Qiang-Hua Wang (ORCID: https://orcid.org/0000-0003-2329-0306)
- Xuegu Wang
- Nana Yang (ORCID: https://orcid.org/0000-0003-1729-3754)
- Biao Ding (ORCID: https://orcid.org/0000-0002-5240-4133)
- Xiang Li (ORCID: https://orcid.org/0000-0002-1030-1662)
- C Jiang
- Danli Du
Institutions
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1627057
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bengbu Medical College