Ferroptosis and mitochondrial ROS are central to SARS-CoV-2-induced hepatocyte death
SARS-CoV-2 disrupts mitochondrial homeostasis and lipid metabolism in hepatocytes, promoting ferroptosis as a major contributor to virus-induced cytopathology. These findings suggest that ferroptosis may play a central role in COVID-19-related liver injury and identify mitochondrial ROS and iron metabolism as potential therapeutic targets.
Authors
- Cinthya Alicia Marcela López (ORCID: https://orcid.org/0000-0003-1603-9156)
- Franco Agustín Sviercz
- M. Victoria Delpino (ORCID: https://orcid.org/0000-0003-2077-8509)
- Patricio Jarmoluk
- Cintia Cevallos (ORCID: https://orcid.org/0000-0002-9268-0853)
- Jorge Quarleri (ORCID: https://orcid.org/0000-0001-5110-8773)
- Rosa Nicole Freiberger (ORCID: https://orcid.org/0009-0001-7461-5687)
Institutions
- Instituto de Investigaciones Biomédicas en Retrovirus y Sida (AR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fcimb.2025.1625928
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Fundación Florencio Fiorini
- Agencia Nacional de Promoción Científica y Tecnológica