Diagnostic performance and clinical utility of metagenomic next-generation sequencing in suspected central nervous system infections: a prospective comparative study

mNGS offers rapid and accurate pathogen detection, outperforming conventional methods in sensitivity and turnaround time, and provides valuable guidance for individualized antimicrobial treatment in CNS infections.

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Publication Details

Journal
Frontiers in Cellular and Infection Microbiology
Published
2025-08-11
DOI
https://doi.org/10.3389/fcimb.2025.1612628
Citations
2
Primary Topic
Bacterial Infections and Vaccines
Type
article
Field-Weighted Citation Impact
2.37
Controls
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article

Diagnostic performance and clinical utility of metagenomic next-generation sequencing in suspected central nervous system infections: a prospective comparative study

Yu Zha, Min Shao, Hua-dong Meng, Chunyan Wang et al.
2 citations
Frontiers in Cellular and Infection Microbiology
Bacterial Infections and Vaccines
2.37
article

Diagnostic performance and clinical utility of metagenomic next-generation sequencing in suspected central nervous system infections: a prospective comparative study

Yu Zha, Min Shao, Hua-dong Meng, Chunyan Wang, Chong-jian Huang, Xiao Zhu, Xiao-guang Cao
article en
2 citations

Abstract

mNGS offers rapid and accurate pathogen detection, outperforming conventional methods in sensitivity and turnaround time, and provides valuable guidance for individualized antimicrobial treatment in CNS infections.

Frontiers in Cellular and Infection MicrobiologyVol. 15
Anhui Medical University (CN), Suzhou Municipal Hospital (CN), Anhui Provincial Hospital (CN), First Affiliated Hospital of Anhui Medical University (CN), Third People's Hospital of Hefei (CN)
Good health and well-being
Openalex Percentile: Top 10%
Bacterial Infections and Vaccines
2.37
DOIOpen Access PDFOpenAlex
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Diagnostic performance and clinical utility of metagenomic next-generation sequencing in suspected central nervous system infections: a prospective comparative study — Yu Zha, Min Shao, et al. · Frontiers in Cellular and Infection Microbiology (2025) | TGRS Research Map | TGRS