Evolution, dissemination, and genetic dynamics of the carbapenem resistance gene blaNDM in China
The diversity of the <i>bla</i> <sub>NDM</sub> and its carrier bacterial strains is continuously increasing, and its transmission range is also expanding. Of greater concern, super-resistant strains co-harboring <i>bla</i> <sub>NDM</sub> and <i>tet(X)</i> genes exhibit high potential for imminent emergence in human populations. Considering that the <i>bla</i> <sub>NDM</sub>-carrier bacteria are increasingly adapted to inter-human spread, the analysis results above can provide methodological and data support for epidemiological surveillance, tracing, and early warning alerts.
Authors
- Lianqun Jin
- Mingliang Chen
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Junjie Yue
- Hongguang Ren (ORCID: https://orcid.org/0000-0002-9151-6090)
- Boqian Wang (ORCID: https://orcid.org/0000-0003-2791-2395)
- Hui Chen (ORCID: https://orcid.org/0000-0003-0340-6180)
- Kexin Li (ORCID: https://orcid.org/0000-0002-1599-7099)
- Hongbin Song
- Shaofu Qiu (ORCID: https://orcid.org/0000-0001-5070-9294)
- Zhixi Peng
- Ling Zhang (ORCID: https://orcid.org/0009-0002-0889-7580)
Institutions
- Army Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Beijing Biocytogen (China) (CN)
- 174th hospital of the People's Liberation Army (CN)
- Southwest Hospital (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fcimb.2025.1608826
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Pathogen and Biosecurity