The Eucommia ulmoides - Achyranthes bidentata pair and their active monomers exert synergistic therapeutic potential for osteoarthritis through the PI3K-AKT pathway
The herbal pair aqueous extract suppresses osteoarthritis via the bioactive component group CHI-PIN, demonstrating synergistic anti-inflammatory effects in MIA rats, likely mediated by PI3K-Akt-regulated apoptosis.
Authors
- Lei Lv (ORCID: https://orcid.org/0000-0003-0675-659X)
- Leilei Bao (ORCID: https://orcid.org/0000-0003-4403-4598)
- Zijun Wang (ORCID: https://orcid.org/0000-0002-6691-1902)
- Xue Jiang (ORCID: https://orcid.org/0000-0003-2109-8660)
- Yangyang Zhan
- Chun Chen (ORCID: https://orcid.org/0000-0002-2178-1438)
- Fangyuan Xie
- Mingzhu Gao (ORCID: https://orcid.org/0000-0002-9002-3390)
- Shenghua Zeng
- Yueying Huang
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fphar.2025.1571884
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00