GPATCH3, a splicing regulator that facilitates tumor immune evasion via the modulation of ATPase activity of DHX15
Our findings suggest GPATCH3 as a critical regulator that governs alternative splicing and immunosuppressive microenvironment remodeling. By modulating the splicing fidelity of key immune genes and altering their expression, GPATCH3 may facilitate immune escape and tumor progression. These results provide mechanistic insights into how RNA splicing factors interface with immune regulation and highlight GPATCH3 as a potential therapeutic target for immunomodulatory cancer therapy.
Authors
- Zhaoying Sheng
- Duanwu Zhang (ORCID: https://orcid.org/0000-0003-2946-846X)
- Gaigai Wei (ORCID: https://orcid.org/0000-0002-9026-7301)
- Jingjing Yi (ORCID: https://orcid.org/0000-0001-9119-2324)
- Haiping Zhao (ORCID: https://orcid.org/0000-0002-3244-1527)
- Nana Wu (ORCID: https://orcid.org/0000-0002-1458-679X)
- Yuqi Zhang (ORCID: https://orcid.org/0000-0001-9577-3150)
- Yihan Wang (ORCID: https://orcid.org/0000-0002-1163-4610)
- Huiling Zhang (ORCID: https://orcid.org/0000-0001-8348-7616)
- Tingting Ren (ORCID: https://orcid.org/0000-0002-6226-6504)
- Zhihan Guo (ORCID: https://orcid.org/0009-0004-7638-6779)
- Jiating Kuang
Institutions
- Ministry of Science and Technology (LA)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1612461
- Citations
- 2
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality