Selective Mono- and Diamination of 2,6-Dibromopyridine for the Synthesis of Diaminated Proligands
Selective mono- or diaminations of 2,6-dibromopyridine were performed using microwave irradiation with water as solvent in 2-2.5 h. The only significant difference between the syntheses was the inclusion of K<sub>2</sub>CO<sub>3</sub> as base and CuI/DMPAO catalyst for the diaminations. The mono- and diaminations had approximately 7 and 2 g isolated yields, respectively. The monoaminated bromopyridines were attached to a TREN scaffolding molecule yielding novel ligands to support extended metal atom chain complexes.
Authors
- Clifford W. Padgett (ORCID: https://orcid.org/0000-0002-8373-1495)
- Christian Richter (ORCID: https://orcid.org/0000-0003-4261-4214)
- Gary L. Guillet (ORCID: https://orcid.org/0000-0002-3696-363X)
- A. F. Underwood
- Matthew T. Roberts (ORCID: https://orcid.org/0000-0002-0639-1634)
- Mark A. Botrous
- Nate T. Lobb
- Emmett M. Neal
- Mathieu A. Sleiman
- Adrian B. Frye
Institutions
- Armstrong Atlantic State University (US)
- Georgia Southern University (US)
- Furman University (US)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1021/acsomega.5c04396
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation