Bioinformatics analysis of laryngeal squamous cell carcinoma based on the high infection rate of HPV in Northwest China
HPV infection rate is 55.65% among laryngeal cancer patients in Northwest China. Ten key genes, namely EGFR, CDC42, PXN, SLC2A1, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), FGF2, ICAM1, ITGB1, PGK1 and ISG15, as well as pathways like proteoglycans in cancer, regulation of actin cytoskeleton and HIF-1 signaling pathway are demonstrated to be of significance in the occurrence and development of laryngeal squamous cell carcinoma. PXN, ITGB1, ISG15, SLC2A1 and ICAM1 are regarded as potential therapeutic targets for HPV-positive laryngeal cancer. PXN and PGK1 are considered as potential prognostic markers for HPV-positive laryngeal cancer.
Authors
- Yuqiao Zhang (ORCID: https://orcid.org/0009-0003-2482-8873)
- Guangke Wang
- Shiqi Yan
- Shurong Li (ORCID: https://orcid.org/0000-0003-1626-7597)
- Ruixia Ma (ORCID: https://orcid.org/0009-0004-5402-5876)
- Fan Guo
Institutions
- Yinchuan First People's Hospital (CN)
- Ningxia Medical University (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-08-11
- DOI
- https://doi.org/10.7717/peerj.19851
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00