Sublingual Therapeutics: A Gateway To Enhanced Drug Absorption

Sublingual drug delivery holds promise for facilitating quicker and more direct absorption of medications into the bloodstream. The sublingual area in the mouth enhances drug absorption, bypassing the liver's first-pass metabolism, resulting in higher bioavailability and improved patient compliance. Sublingual medications can help children, the elderly, and individuals with mental health disorders or those that have dysphasia. Over time, these new options help in improving treatment management by making medication easier and more convenient. Because of their potential for emergency treatment, there is a growing demand for sublingual drug delivery. In contrast to the oral cavity's palatal and buccal areas, the sublingual region is more permeable; thus, fast-dissolving sublingual tablets have the potential to significantly outperform existing treatment options for certain patient populations, including elderly and paediatric patients. Keywords: Sublingual drug delivery, absorption of drug, superior permeability, avoid hepatic first-pass metabolism, bioavailability.

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Publication Details

Journal
European journal of parenteral & pharmaceutical sciences
Published
2025-07-11
DOI
https://doi.org/10.37521/ejpps302012
Primary Topic
Pharmacological Effects of Natural Compounds
Type
article
Field-Weighted Citation Impact
0.00
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article

Sublingual Therapeutics: A Gateway To Enhanced Drug Absorption

G. N. Darwhekar, Ashish Gupta, Sumeet Dwivedi, Pravin Kumar Sharma et al.
European journal of parenteral & pharmaceutical sciences
Pharmacological Effects of Natural Compounds
article

Sublingual Therapeutics: A Gateway To Enhanced Drug Absorption

G. N. Darwhekar, Ashish Gupta, Sumeet Dwivedi, Pravin Kumar Sharma, Neeraj Vishwakarma
article en

Abstract

Sublingual drug delivery holds promise for facilitating quicker and more direct absorption of medications into the bloodstream. The sublingual area in the mouth enhances drug absorption, bypassing the liver's first-pass metabolism, resulting in higher bioavailability and improved patient compliance. Sublingual medications can help children, the elderly, and individuals with mental health disorders or those that have dysphasia. Over time, these new options help in improving treatment management by making medication easier and more convenient. Because of their potential for emergency treatment, there is a growing demand for sublingual drug delivery. In contrast to the oral cavity's palatal and buccal areas, the sublingual region is more permeable; thus, fast-dissolving sublingual tablets have the potential to significantly outperform existing treatment options for certain patient populations, including elderly and paediatric patients. Keywords: Sublingual drug delivery, absorption of drug, superior permeability, avoid hepatic first-pass metabolism, bioavailability.

European journal of parenteral & pharmaceutical sciences
Good health and well-being
Openalex Percentile: Top 73%
Pharmacological Effects of Natural Compounds
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