Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement

Through single-cell sequencing, <i>in vitro</i> multilineage induction, co-culture systems, and a mouse model of LPS-induced acute infection, this study systematically elucidates the close interplay between jawbone MSCs and HSCs, as well as their pivotal roles in immune modulation and anti-infective responses. The findings demonstrate that jawbone MSCs not only exhibit robust multilineage differentiation potential but also secrete CXCL12 and activate key B cell transcription factors (such as PAX5). This process significantly promotes HSC differentiation into B cells, improves survival rates in infected mice, and attenuates systemic inflammation. These results establish a strong foundation for further investigation into the applications of jawbone MSCs in immune regulation and disease therapy.

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Publication Details

Journal
Frontiers in Bioengineering and Biotechnology
Published
2025-08-11
DOI
https://doi.org/10.3389/fbioe.2025.1596143
Primary Topic
Mesenchymal stem cell research
Type
article
Field-Weighted Citation Impact
0.00

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article

Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement

Tingwei Lu, Zihan Huang, S. Sun, Lei Shen et al.
Frontiers in Bioengineering and Biotechnology
Mesenchymal stem cell research
article

Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement

Tingwei Lu, Zihan Huang, S. Sun, Lei Shen, Zijian Zhang, Lingyong Jiang, Jiping Sun, Paul R. Cooper, Qinggang Dai, Qianye Chen, Yuanqi Liu, Mei Li, Xinyu Wang, Houwen Pan, Xiangru Huang
article en

Abstract

Through single-cell sequencing, <i>in vitro</i> multilineage induction, co-culture systems, and a mouse model of LPS-induced acute infection, this study systematically elucidates the close interplay between jawbone MSCs and HSCs, as well as their pivotal roles in immune modulation and anti-infective responses. The findings demonstrate that jawbone MSCs not only exhibit robust multilineage differentiation potential but also secrete CXCL12 and activate key B cell transcription factors (such as PAX5). This process significantly promotes HSC differentiation into B cells, improves survival rates in infected mice, and attenuates systemic inflammation. These results establish a strong foundation for further investigation into the applications of jawbone MSCs in immune regulation and disease therapy.

Frontiers in Bioengineering and BiotechnologyVol. 13
Shanghai Jiao Tong University (CN), Ruijin Hospital (CN), Shanghai Ninth People's Hospital (CN)
National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality, Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University
Good health and well-being
Openalex Percentile: Top 72%
Mesenchymal stem cell research
DOIOpen Access PDFOpenAlex
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