Mycobacterium tuberculosis Modulates the Expansion of Terminally Exhausted CD4+ and CD8+ T-Cells in Individuals with HIV-TB Co-Infection
These findings suggest that Mtb co-infection exacerbates immune exhaustion in co-infected individuals. Targeting ICMs with pharmacological immune checkpoint inhibitors (ICIs) offers a promising approach for better clinical management of co-infected individuals.
Authors
- Sunil Arora (ORCID: https://orcid.org/0000-0002-8294-5360)
- Poonam Sharma (ORCID: https://orcid.org/0000-0002-3725-3509)
- Komal Sharma
Institutions
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Pathogens
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3390/pathogens14080802
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Arthritis National Research Foundation
- Postgraduate Institute of Medical Education and Research, Chandigarh
- National Research Foundation
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Ministry of Health and Family Welfare
- Science and Engineering Research Board