The Small Molecule Inhibitor of the Type III Secretion System Fluorothiazinone Affects Flagellum Surface Presentation and Restricts Motility in Gram-Negative Bacteria
FT selectively inhibits flagellum-based motility in Gram-negative bacteria. Obtained data suggested FT interference with flagellum biosynthesis rather than disruption of rotation. Motility inhibition can contribute to FT therapeutic effects on Gram-negative bacterial infections.
Authors
- Gintsburg Al (ORCID: https://orcid.org/0000-0003-1769-5059)
- Anna B. Sheremet (ORCID: https://orcid.org/0000-0002-5210-5010)
- Egor V. Kalinin (ORCID: https://orcid.org/0000-0002-4478-3225)
- M. M. Vasiliev (ORCID: https://orcid.org/0000-0002-0425-1152)
- S. G. Andreevskaya (ORCID: https://orcid.org/0000-0003-4704-4329)
- N. V. Shevlyagina (ORCID: https://orcid.org/0000-0001-9651-1654)
- V. G. Zhukhovitsky (ORCID: https://orcid.org/0000-0002-4653-2446)
- Mariam Abdulkadieva
- O. F. Petrov
- Svetlana A. Ermolaeva (ORCID: https://orcid.org/0000-0003-3396-6816)
- N. E. Bondareva (ORCID: https://orcid.org/0000-0002-5244-2965)
- Elena V. Sysolyatina (ORCID: https://orcid.org/0000-0002-1168-4159)
- Lydia N. Kapotina
- Nailya А. Zigangirova (ORCID: https://orcid.org/0000-0003-3188-1608)
- Alexey Slonov
Institutions
- Sechenov University (RU)
- Gamalei Institute of Epidemiology and Microbiology (RU)
- Russian Medical Academy of Continuous Professional Education (RU)
- Joint Institute for High Temperatures (RU)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3390/antibiotics14080820
- Citations
- 2
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 3.60
Funders
- Ministry of Health of the Russian Federation