Cardiovascular Health Optimization Through Life’s Essential 8 Scores Reduces Gestational Diabetes Risk: Mediation by Platelet Activity and Inflammatory Pathways in a Nationwide Cohort
As the first study to integrate CVH metrics with platelet/inflammatory biomarkers in GDM pathogenesis, our findings demonstrate that optimizing LE8 scores, particularly through BMI, blood pressure, and lipid control, significantly mitigates GDM risk and complications. Integrating LE8 assessment at first prenatal visit may enable early risk stratification and personalized interventions.
Authors
- Qiankun Yang (ORCID: https://orcid.org/0000-0003-2850-6065)
- Lidan He (ORCID: https://orcid.org/0000-0002-7418-6886)
- Xia Zhang (ORCID: https://orcid.org/0000-0002-9040-1486)
- Xue‐Mei Li (ORCID: https://orcid.org/0000-0002-9361-1753)
- Jianbo Wu (ORCID: https://orcid.org/0000-0002-1349-6290)
- Chen Chen
Institutions
- Fujian Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- International Journal of Women s Health
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/ijwh.s536082
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00