Application of prolonged veno-venous hemodiafiltration in intensive care for patients with severe thermal injuries

Burn disease in the stage of acute burn toxemia represents a symptom complex of interrelated and mutually aggravating pathological conditions, which can be appropriately grouped under the term "syndrome of mutual burdening". This primarily includes systemic inflammatory response syndrome (SIRS) characterized by severe endotoxemia, immunosuppression, and hypermetabolic syndrome. One of the key components of multimodal treatment for severe thermal injury is the implementation of comprehensive detoxification therapy, which makes it possible to prevent the development of burn disease complications and improves the overall prognosis. The use of hemodiafiltration procedures in patients during the burn toxemia stage leads to significant improvements in hemodynamics, pulmonary oxygenation, and correction of pathological disturbances in homeostasis. The obtained data demonstrate new possibilities in the intensive care of patients with deep burns. Incorporating hemodiafiltration into the treatment protocol may reduce mortality and shorten the duration of hospitalization