Cecal microbiome transplantation without antibiotic preconditioning standardizes murine microbiomes
We propose that CMT without antibiotic preconditioning provides increased control over host microbial composition, enabling expanded utility, accuracy, and relevance for nonclinical drug toxicity and therapeutic effect studies in laboratory mice, with minimal additional costs.
Authors
- Mark D. Driscoll
- Ion Măndoiu (ORCID: https://orcid.org/0000-0002-4818-0237)
- Thi Dong Binh Tran
- Eric W. Jackson (ORCID: https://orcid.org/0000-0002-7666-3762)
- Elias M. Oziolor (ORCID: https://orcid.org/0000-0002-4078-1054)
- Darien Capunitan
- Rye Howard-Stone
- Philip Gerwin
Institutions
- University of Connecticut (US)
- Pfizer (United States) (US)
- Coherus BioSciences (United States) (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.3389/fmicb.2025.1632210
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81