Prognostic Significance of R-Loops in Lung Adenocarcinoma: Implications for Immune Response and Drug Sensitivity
The R-loops Score represents a promising prognostic tool for LUAD, offering valuable insights into survival outcomes, immune characteristics and drug responsiveness. Notably, qPCR and Western blot validation consistently confirmed EIF3B as a key gene, further supporting their potential as biomarkers. These results support future research and serve as a reference for the personalized precision treatment of LUAD.
Authors
- Shuan Rao (ORCID: https://orcid.org/0000-0002-5268-7006)
- Kaican Cai (ORCID: https://orcid.org/0000-0003-4664-6694)
- Jianjun Jiang (ORCID: https://orcid.org/0000-0003-0368-0999)
- Fangfang Li (ORCID: https://orcid.org/0000-0001-7695-7958)
- Yun Liang (ORCID: https://orcid.org/0000-0002-0364-6195)
- Xuguang Rao
- Yinghua He (ORCID: https://orcid.org/0009-0005-4461-2863)
- Biying Men (ORCID: https://orcid.org/0009-0005-8689-1928)
- Yingxin Zhang (ORCID: https://orcid.org/0000-0002-0996-600X)
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- Cancer Management and Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/cmar.s533571
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00