Outcomes and Predictors of Amputation After Endovascular Revascularization in Diabetic Foot Disease with Peripheral Artery Involvement

Background: Peripheral arterial disease (PAD) is significantly more prevalent in diabetic populations and is a major contributor to non-traumatic lower limb amputations.Aim: This study assesses outcomes of percutaneous revascularization in diabetic PAD patients, comparing clinical characteristics between those who underwent amputation and those who did not. Study Design:A single center retrospective observational study. Methods:The study was conducted on 100 diabetic PAD patients undergoing endovascular revascularization between March 2023 and April 2024.Clinical classifications and laboratory parameters [hemoglobin A1c (HbA1c), renal function, C-reactive protein, low-density lipoprotein] were analyzed at baseline and 6 months.Results: Amputation occurred in 15 patients (15%).These patients had significantly higher HbA1c (10.5 vs. 8.8, p<0.001), creatinine (1.52 vs. 0.89, p<0.001), and lower estimated glomerular filtration rate (47 vs. 89, p<0.001).PAD severity scores (Rutherford, Fontaine, Wagner, WIfI, TASC II) were all significantly higher in the amputation group.Receiver operating characteristic (ROC) analysis showed Wagner classification had the best predictive value (area under the ROC curve 0.982). Conclusion:Advanced PAD in diabetics correlates with worse metabolic control and renal dysfunction.Early diagnosis and revascularization are critical to avoid amputation.