miR-145-Mediated Tumor Suppression in Bladder Urothelial Carcinoma via Targeting the ADAMTS5/Wnt Signaling Axis
The present study revealed that miR-145 negatively regulates the expression of ADAMTS5. This regulatory effect of miR-145 may be associated with the Wnt/β‑catenin signaling pathway. Therefore, miR-145 has the potential to be used as a biomarker for predicting the progression of BLCA.
Authors
- Xi Huang (ORCID: https://orcid.org/0000-0003-0306-1127)
- Chunyan Mao (ORCID: https://orcid.org/0000-0001-8118-3360)
- Jun Chen (ORCID: https://orcid.org/0000-0002-4459-8804)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-8467-5042)
- Zhichun Feng (ORCID: https://orcid.org/0000-0002-9622-4062)
- Ming Fu (ORCID: https://orcid.org/0000-0002-5327-780X)
Institutions
- Ezhou Central Hospital (CN)
Publication Details
- Journal
- Cureus
- Published
- 2025-08-11
- DOI
- https://doi.org/10.7759/cureus.89796
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00