TYK2 rs34536443 (P1104A) Variant Suppresses ICAM1-Mediated Inflammation: Insights From Mendelian Randomization and Functional Analyses
This study identifies ICAM1 as a key mediator in psoriasis via SMR analysis and implicates the TYK2 SNP rs34536443 in its regulation. The TYK2-P1104A variant attenuates ICAM1 and cytokine expression, and Deucravacitinib downregulates ICAM1 in vivo. These findings provide mechanistic insights into the TYK2-ICAM1 axis and support the therapeutic potential of TYK2 inhibitors for psoriasis.
Authors
- Bin Zhang (ORCID: https://orcid.org/0000-0003-0149-5669)
- Kan Ze (ORCID: https://orcid.org/0000-0002-9354-2380)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-6315-0936)
- Guangyao Xu
- Bowen Dai (ORCID: https://orcid.org/0009-0007-2294-0772)
- Ye Tang (ORCID: https://orcid.org/0000-0001-5538-8442)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Psoriasis Targets and Therapy
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/ptt.s535434
- Citations
- 1
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.05