Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
Prostate cancer progression is sustained by the simultaneous activation of pathways involving lipid uptake and de novo synthesis. In this context, miR-137 inhibits adipogenic differentiation and may reduce lipid uptake by tumor cells by modulating the PPAR/ p160/ESRRA axis, considerably attenuating metabolic effects and suppressing prostate tumorigenesis.
Authors
- Miguel Srougi (ORCID: https://orcid.org/0000-0002-4545-0596)
- Feres Camargo Maluf (ORCID: https://orcid.org/0000-0002-3756-1624)
- Juliana Alves de Camargo (ORCID: https://orcid.org/0000-0001-5624-3798)
- Ruan Pimenta (ORCID: https://orcid.org/0000-0002-3423-5647)
- Nayara Izabel Viana (ORCID: https://orcid.org/0000-0003-4505-8508)
- Iran A. Silva (ORCID: https://orcid.org/0000-0001-5441-790X)
- Karina Serafim da Silva (ORCID: https://orcid.org/0000-0003-4854-9302)
- Vanessa Ribeiro Guimarães (ORCID: https://orcid.org/0000-0003-3021-722X)
- Kátia Ramos Moreira Leite (ORCID: https://orcid.org/0000-0002-2615-7730)
- Sabrina T. Reis (ORCID: https://orcid.org/0000-0002-3564-3597)
- Gabriel Arantes dos Santos (ORCID: https://orcid.org/0000-0003-1602-9193)
Institutions
- University of California, San Francisco (US)
- Universidade do Estado de Minas Gerais (BR)
- D’Or Institute for Research and Education (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Hospital Sírio-Libanês (BR)
Publication Details
- Journal
- Einstein (São Paulo)
- Published
- 2025-01-01
- DOI
- https://doi.org/10.31744/einstein_journal/2025ao1601
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade de São Paulo