Overt hepatic encephalopathy after elective and preemptive TIPS: Risk factors and prognosis

This study demonstrates that overt hepatic encephalopathy (OHE) remains a frequent complication after both preemptive and elective transjugular intrahepatic portosystemic shunt (TIPS) placement, though the underlying risk factors differ depending on the clinical indication. Identifying predictors such as cardiac disease, sarcopenia, and baseline ammonia can help refine patient selection and post-TIPS management. The association between OHE and adverse outcomes highlights the need for closer surveillance and timely intervention. Early referral for liver transplantation should be considered in patients who develop persistent or refractory OHE after TIPS.

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Publication Details

Journal
JHEP Reports
Published
2025-08-11
DOI
https://doi.org/10.1016/j.jhepr.2025.101548
Citations
3
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
3.97
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article

Overt hepatic encephalopathy after elective and preemptive TIPS: Risk factors and prognosis

Dominique Thabut, Philippe Sultanik, Charles Roux, Charlotte Bouzbib et al.
3 citations
JHEP Reports
Liver Disease and Transplantation
3.97
article

Overt hepatic encephalopathy after elective and preemptive TIPS: Risk factors and prognosis

Dominique Thabut, Philippe Sultanik, Charles Roux, Charlotte Bouzbib, Nicolas Weiss, Asier Rabasco Meneghetti, Hélène Larrue, Christophe Bureau, Lyes Kheloufi, Marika Rudler, José Ursic Bedoya, S. Mouri, Paul Primard, Mélisande Jorus, Benjamin Poussot
article en
3 citations

Abstract

This study demonstrates that overt hepatic encephalopathy (OHE) remains a frequent complication after both preemptive and elective transjugular intrahepatic portosystemic shunt (TIPS) placement, though the underlying risk factors differ depending on the clinical indication. Identifying predictors such as cardiac disease, sarcopenia, and baseline ammonia can help refine patient selection and post-TIPS management. The association between OHE and adverse outcomes highlights the need for closer surveillance and timely intervention. Early referral for liver transplantation should be considered in patients who develop persistent or refractory OHE after TIPS.

JHEP ReportsVol. 7(11)
Inserm (FR), Université de Montpellier (FR), Helmholtz-Zentrum Dresden-Rossendorf (DE), Sorbonne Université (FR), Centre Hospitalier Universitaire de Montpellier (FR), Assistance Publique – Hôpitaux de Paris (FR), Pitié-Salpêtrière Hospital (FR), Centre de Recherche Saint-Antoine (FR), OncoRay (DE), Hôpital Saint Eloi (FR), Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR), University Hospital Carl Gustav Carus (DE), Technische Universität Dresden (DE)
Openalex Percentile: Top 6%
Liver Disease and Transplantation
3.97
DOIOpen Access PDFOpenAlex
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