Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses
These findings support that the comorbidity among psychiatric disorders, SDD, and CLBP is due to the contribution of direct effects and shared biology linking these health outcomes. These pleiotropic mechanisms, together with sociocultural factors, play a key role in shaping the SDD-CLBP comorbidity patterns that have been observed across the psychopathology spectrum.
Authors
- Brenda Cabrera‐Mendoza (ORCID: https://orcid.org/0000-0003-4729-9997)
- Renato A Polimanti (ORCID: https://orcid.org/0000-0003-0745-6046)
- Mihaela Aslan (ORCID: https://orcid.org/0000-0002-5041-010X)
- Eleni Friligkou (ORCID: https://orcid.org/0009-0003-3682-0991)
- Jun He (ORCID: https://orcid.org/0000-0003-4467-7649)
- Mihir Gupta (ORCID: https://orcid.org/0000-0003-1329-2906)
- Dan Qiu (ORCID: https://orcid.org/0000-0002-6049-2858)
Institutions
- Yale University (US)
- VA Connecticut Healthcare System (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100588
- Citations
- 2
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- One Mind
- National Institutes of Health
- National Institute of Mental Health
- National Institute on Drug Abuse