An Ingeniously Designed Skin Lesion Classification Model Across Clinical and Dermatoscopic Datasets

<b>Background</b>: Skin cancer diagnosis faces critical challenges due to the visual similarity of lesions and dataset limitations. <b>Methods</b>: This study introduces HybridSkinFormer, a robust deep learning model designed to classify skin lesions from both clinical and dermatoscopic images. The model employs a two-stage architecture: a multi-layer ConvNet for local feature extraction and a residual-learnable multi-head attention module for global context fusion. A novel activation function (StarPRelu) and Enhanced Focal Loss (EFLoss) address neuron death and class imbalance, respectively. <b>Results</b>: Evaluated on a hybrid dataset (37,483 images across nine classes), HybridSkinFormer achieved state-of-the-art performance with an overall accuracy of 94.2%, a macro precision of 91.1%, and a macro recall of 91.0%, outperforming nine CNN and ViT baselines. <b>Conclusions</b>: Its ability to handle multi-modality data and mitigate imbalance highlights its clinical utility for early cancer detection in resource-constrained settings.