Anti-neutrophil Cytoplasmic Antibody (ANCA)-Negative Pauci-Immune Crescentic Glomerulonephritis: A Case Series From a Tertiary Care Hospital in South India

ANCA-negative PICGN represents a severe crescentic glomerulonephritis with significant diagnostic and therapeutic implications. Prompt renal biopsy and early immunosuppressive therapy are essential for renal salvage. Despite treatment, outcomes remain variable, emphasizing the need for heightened clinical suspicion and timely intervention. ANCA-negative PICGN is an aggressive glomerular disease. Renal biopsy is indispensable in seronegative cases of rapid renal deterioration. Due to its aggressive nature, this form of glomerular disease requires timely histopathological evaluation and the immediate initiation of immunosuppressive therapy, especially when autoimmune serology is negative. Although partial recovery is possible, mortality remains a concern.