Human monocyte inflammation in patients with Lp(a) or atherosclerotic cardiovascular disease is not accompanied by changes in chromatin accessibility in circulating classical monocytes
While subjects with high Lp(a) levels showed enhanced monocyte inflammation, no differences in chromatin accessibility were detected. This suggests that the pro-inflammatory signature of Lp(a) and ASCVD on monocytes is regulated at a level other than chromatin accessibility.
Authors
- Koen H.M. Prange (ORCID: https://orcid.org/0000-0002-9835-1735)
- Jordan M Kraaijenhof (ORCID: https://orcid.org/0000-0001-7566-6403)
- Nick S. Nurmohamed (ORCID: https://orcid.org/0000-0001-9045-6009)
- Bram W. van Os (ORCID: https://orcid.org/0000-0002-2327-0527)
- Menno P.J. de Winther (ORCID: https://orcid.org/0000-0002-4038-6636)
- Rosalie W.M. Kempkes (ORCID: https://orcid.org/0000-0002-6232-5295)
- Yannick Kaiser (ORCID: https://orcid.org/0000-0001-6869-0042)
- Guillermo R. Griffith (ORCID: https://orcid.org/0000-0002-3983-1499)
- Esther Lutgens (ORCID: https://orcid.org/0000-0002-2609-5744)
- Erik S.G. Stroes (ORCID: https://orcid.org/0000-0001-9555-6260)
- Annette E. Neele (ORCID: https://orcid.org/0000-0001-9029-3991)
Institutions
- Amsterdam University Medical Centers (NL)
- Amsterdam University of Applied Sciences (NL)
Publication Details
- Journal
- Journal of clinical lipidology
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1016/j.jacl.2025.08.003
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80