P62/Sequestosome1 deficiency disrupts antioxidant and stress homeostasis during acute pancreatitis without exacerbating inflammation
These findings suggest that while p62 deletion does not affect overall AP severity, it compromises redox homeostasis and metabolic recovery, highlighting a protective role for p62 during pancreatic injury.
Authors
- Hiroshi Nishiura (ORCID: https://orcid.org/0000-0003-0941-8537)
- Jingren Wang (ORCID: https://orcid.org/0000-0002-1859-8018)
- Eiji Warabi
- Masaki Ohmuraya (ORCID: https://orcid.org/0000-0002-8352-6598)
- Mai Imasaka
- Satoru Takahashi (ORCID: https://orcid.org/0000-0002-8540-7760)
- Wenting Chen
- Yuki Takeda
Institutions
- Hyogo Medical University (JP)
- University of Tsukuba (JP)
- Hyogo University (JP)
Publication Details
- Journal
- Pancreatology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.pan.2025.07.416
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00