A Raman-microfluidic system for single bacterium identification, and sorting, and its application in bacterial properties analysis
We built a Raman-Microfluidic system that can realize high-quality single bacterium identification and sorting. The Raman spectrum of a single bacterium can be detected stably and with high quality on the move. And a Raman spectral database of several bacterial species was preliminary established, which laid the foundation for the rapid bacterial identification. The establishment of our systems and databases is of great significance for rapid diagnosis of diseases and dynamic research on drug resistance.
Authors
- Weigang Ma
- Yujing Bi (ORCID: https://orcid.org/0000-0002-1228-9628)
- Xiang‐Qian Liu (ORCID: https://orcid.org/0000-0002-9713-0498)
- Fengyi Li (ORCID: https://orcid.org/0000-0002-0744-2798)
- Aoran Fan (ORCID: https://orcid.org/0000-0001-7379-9958)
- Xing Zhang (ORCID: https://orcid.org/0000-0001-7294-9598)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0001-7222-1089)
- Zixin Shu
Institutions
- Academy of Military Medical Sciences (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.aca.2025.344530
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Association for Science and Technology
- National Natural Science Foundation of China
- Tsinghua University