Pharmacological Profile of Yashtimadhu in Urdwajaturu Vikara - A Synergistic View of Ayurveda and Modern Science

In present era, traditional medicines are gaining global recognition for their significant therapeutic potential and holistic approach to healing. There are many plants having great therapeutic significance. Yashtimadhu (Glycyrrhiza glabra Linn.) is a significant and widely utilized classical herbal medicinal plant, extensively referenced in the Vedas and Samhitas for its broad therapeutic applications. It possesses numerous phytochemical constituents such as glycyrrhizin, glycyrrhetinic acid, asparagine, isoflavones, and triterpenoids, which exhibit potent pharmacological effects. These constituents contribute to its efficacy in managing various diseases, particularly those affecting the head and neck region, Renowned for its Rasayana (rejuvenating) properties, Yashtimadhu plays a multifaceted role in promoting the overall health of organs located above the clavicle. The primary active component of Yashtimadhu, glycyrrhizin, constitutes about 2–9% of the root, while glycyrrhetinic acid is present in concentrations ranging from 0.5–0.9%. Other important constituents include flavonoids, chalcones, coumarins, sterols, amino acids, amines, lignans, gums, and volatile oils. These phytochemicals offer a broad spectrum of pharmacological actions, such as anti-ulcer, wound healing, anti-inflammatory, antioxidant, anti- tussive, and cognitive function enhancing activities, along with benefits in managing eye disorders.[1] This study endeavors to provide conceptual and analytical review of efficacy of Yashtimadhu in Urdhwajatrugata Vikaras by drawing insights from various Ayurvedic literature source as well as contemporary scientific perspectives to highlight its therapeutic potential.