Reynoutrin activates Sirt1/Foxo3a and Nrf2 pathway via targeting Fyn to ameliorate diabetic nephropathy
Our results emphasize the efficacy of reynoutrin in treating DN and demonstrate its broader therapeutic potential through Fyn inhibition.
Authors
- Xuting Zhang (ORCID: https://orcid.org/0000-0002-1522-4694)
- Min Wen
- Lìyı̌n Liáng (ORCID: https://orcid.org/0000-0001-9831-4793)
- Linjie Pan
- Shanshan Li
- Peiqing Liu (ORCID: https://orcid.org/0000-0002-0997-363X)
- Heqing Huang (ORCID: https://orcid.org/0000-0002-6135-9901)
- Weihua Liu (ORCID: https://orcid.org/0000-0002-7002-8370)
- Haiming Xiao
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Guangdong Pharmaceutical University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Integrated Chinese Medicine (China) (HK)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.phymed.2025.157158
- Citations
- 4
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.22