Synthesis of axially chiral 5,5′-substituted 2,2′-bipyridine ligands and their application in palladium-catalyzed asymmetric oxidative [2 + 2] annulation
A series of axially chiral 5,5'-substituted 2,2'-bipyridine ligands featuring tunable properties have been synthesized. These ligands have been successfully applied to palladium-catalyzed asymmetric oxidative [2 + 2] annulation of arylboronic acids and alkenes, providing a diverse range of chiral benzocyclobutenes in excellent enantioselectivities with a broad substrate scope.
Authors
- Jian Chen (ORCID: https://orcid.org/0000-0002-2097-5740)
- Yong‐Gui Zhou (ORCID: https://orcid.org/0000-0002-3321-5521)
- Bo Wu (ORCID: https://orcid.org/0009-0007-0217-2331)
- Kai Xue (ORCID: https://orcid.org/0000-0003-4210-6965)
- Yuqing Bai (ORCID: https://orcid.org/0009-0004-1428-3459)
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01000d
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province
- Dalian Institute of Chemical Physics
- National Key Research and Development Program of China