TyG-BMI Index as a Potential Predictor of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus

This study aimed to validate the triglyceride glucose-body mass index (TyG-BMI) as a predictor of ultrasonography-confirmed non-alcoholic fatty liver disease (NAFLD) in hospitalized patients with type 2 diabetes mellitus (T2DM). In this retrospective cohort analysis of 76 T2DM patients, NAFLD was diagnosed using standardized abdominal ultrasonography. Multivariate logistic regression adjusted for age and sex revealed that patients with NAFLD exhibited significantly higher TyG-BMI levels than non-NAFLD controls (p<0.05). Each 10-unit increment in TyG-BMI increased NAFLD risk by 30% (adjusted OR=1.3, 95% CI: 1.1–1.6, p<0.05). Notably, the highest TyG-BMI tertile demonstrated an 18.3-fold elevated risk of NAFLD compared to the lowest tertile (adjusted OR=18.3, 95% CI: 3.1–107.7, p<0.05). These findings establish TyG-BMI as a robust predictor of NAFLD in T2DM, with extreme risk elevation in high-index patients. Integration of TyG-BMI into diabetes management protocols may enable early risk stratification and targeted interventions.